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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
GUCY1A3
All Species:
15.15
Human Site:
Y660
Identified Species:
27.78
UniProt:
Q02108
Number Species:
12
Phosphosite Substitution
Charge Score:
0
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q02108
NP_000847.2
690
77452
Y660
I
C
H
F
L
D
A
Y
Q
Q
G
T
N
S
K
Chimpanzee
Pan troglodytes
XP_522169
734
81883
R702
I
C
Y
F
L
E
V
R
T
G
P
K
P
P
K
Rhesus Macaque
Macaca mulatta
Dog
Lupus familis
XP_536590
746
83063
R714
I
C
Y
F
L
E
V
R
T
G
P
K
Q
P
K
Cat
Felis silvestris
Mouse
Mus musculus
Q9ERL9
691
77555
Y660
I
C
H
F
L
D
A
Y
H
H
Q
G
P
N
S
Rat
Rattus norvegicus
P19686
690
77548
Y659
I
C
H
F
L
D
A
Y
Q
H
Q
G
P
N
S
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001510214
690
77963
Y660
I
C
H
F
L
D
A
Y
H
Q
E
T
N
S
K
Chicken
Gallus gallus
XP_420375
688
77848
Y658
I
C
Y
F
L
D
A
Y
I
Q
G
T
S
S
Q
Frog
Xenopus laevis
Zebra Danio
Brachydanio rerio
XP_002667138
626
69572
E603
L
M
A
L
K
M
M
E
L
S
E
E
M
L
T
Tiger Blowfish
Takifugu rubipres
NP_001027855
675
75480
F652
R
Q
E
L
P
A
N
F
P
E
D
I
P
G
V
Fruit Fly
Dros. melanogaster
Q07093
676
75644
L645
G
T
E
T
C
Y
F
L
E
S
F
R
N
P
A
Honey Bee
Apis mellifera
NP_001011650
699
78655
D670
G
T
S
Y
F
L
N
D
Y
K
H
K
D
V
D
Nematode Worm
Caenorhab. elegans
O02298
688
78384
G636
Q
S
I
Y
Q
E
E
G
G
Q
Q
E
N
L
T
Sea Urchin
Strong. purpuratus
P16065
1125
126238
Y1096
L
L
G
Q
D
P
S
Y
K
I
T
K
V
K
P
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
47.9
N.A.
47.3
N.A.
89.5
89.2
N.A.
87.5
84
N.A.
39.1
58.9
34.2
35
29.5
22.6
Protein Similarity:
100
63
N.A.
62.4
N.A.
94.9
94.9
N.A.
93.4
92.3
N.A.
54.3
73.6
53.3
55.3
48.2
36.3
P-Site Identity:
100
33.3
N.A.
33.3
N.A.
53.3
60
N.A.
86.6
73.3
N.A.
0
0
6.6
0
13.3
6.6
P-Site Similarity:
100
46.6
N.A.
46.6
N.A.
60
66.6
N.A.
86.6
93.3
N.A.
6.6
13.3
13.3
20
26.6
26.6
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
0
8
0
0
8
39
0
0
0
0
0
0
0
8
% A
% Cys:
0
54
0
0
8
0
0
0
0
0
0
0
0
0
0
% C
% Asp:
0
0
0
0
8
39
0
8
0
0
8
0
8
0
8
% D
% Glu:
0
0
16
0
0
24
8
8
8
8
16
16
0
0
0
% E
% Phe:
0
0
0
54
8
0
8
8
0
0
8
0
0
0
0
% F
% Gly:
16
0
8
0
0
0
0
8
8
16
16
16
0
8
0
% G
% His:
0
0
31
0
0
0
0
0
16
16
8
0
0
0
0
% H
% Ile:
54
0
8
0
0
0
0
0
8
8
0
8
0
0
0
% I
% Lys:
0
0
0
0
8
0
0
0
8
8
0
31
0
8
31
% K
% Leu:
16
8
0
16
54
8
0
8
8
0
0
0
0
16
0
% L
% Met:
0
8
0
0
0
8
8
0
0
0
0
0
8
0
0
% M
% Asn:
0
0
0
0
0
0
16
0
0
0
0
0
31
16
0
% N
% Pro:
0
0
0
0
8
8
0
0
8
0
16
0
31
24
8
% P
% Gln:
8
8
0
8
8
0
0
0
16
31
24
0
8
0
8
% Q
% Arg:
8
0
0
0
0
0
0
16
0
0
0
8
0
0
0
% R
% Ser:
0
8
8
0
0
0
8
0
0
16
0
0
8
24
16
% S
% Thr:
0
16
0
8
0
0
0
0
16
0
8
24
0
0
16
% T
% Val:
0
0
0
0
0
0
16
0
0
0
0
0
8
8
8
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
24
16
0
8
0
47
8
0
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _